Provided is a therapeutic agent for diseases associated with a cholinergic property of the central nervous system (CNS) and/or the peripheral nervous system (PNS), diseases associated with the contraction of smooth muscle, incretion diseases, diseases associated with neuronal degeneration and the like, said therapeutic agent comprising a compound represented by formula (I) [wherein X-Y-Z represents N-CO-NR4AR4B or the like R1 represents a phenyl group or the like R2A and R2B may be the same as or different from each other and independently represent a hydrogen atom or the like R3A to R3D and R6 may be the same as or different from one another and independently represent a hydrogen atom or the like R4A and R4B may be the same as or different from each other and independently represent an aryl group or the like and n represents 1 or 2] or a pharmaceutically acceptable salt thereof and having a potent activity of regulating an α7 nicotinic acetylcholine receptor (an α7 nAChR).Se proporciona un agente terapéutico para enfermedades asociadas con una propiedad colinérgica del sistema nervioso central (CNS) y/o el sistema nervioso periférico (PNS), enfermedades asociadas con la contracción del músculo liso, la enfermedad de increción, enfermedades asociadas con la degeneración neuronal y similares, dicho agente terapéutico comprende un compuesto representado por la fórmula (I): (ver Fórmula) [en donde X-Y-Z representa N-CO-NR4AR4B o lo similar R1 representa un grupo fenilo o similar R2A y R2B pueden ser iguales o diferentes del otro y representan independientemente un átomo de hidrógeno o similar R3A a R3D y R6 pueden ser iguales o diferentes uno del otro y representan independientemente un átomo de hidrógeno o similar R4A y R4B pueden ser iguales o diferentes uno del otro y representar independientemente un grupo arilo o similar y n representa 1 o 2] o una sal farmacéuticamente aceptable del mismo y con una potente actividad de regulación de un receptor nicotínico de ac
