The present invention relates to new and improved interleukin-7 polypeptides,as wellas compositions comprising the same, their preparation and uses. The inventionmore particularly relates to hyperglycosylated IL-7 polypeptides havingimprovedproperties, as well as their manufacture and therapeutic uses. The inventionalsodiscloses novel IL-7 polypeptides having modified amino acid sequencescontainingartificially created glycosylation site(s), as well as corresponding nucleicacidmolecules, vectors and recombinant host cells. The invention also relates tothe useof such polypeptides, cells or nucleic acids for curative or preventivetreatment ofmammalian subjects, including human subjects.
