William L. Jorgensen,Juliana Ruiz-Caro,Andrew D. Hamilton
申请号：
US11991583
公开号：
US09018209B2
申请日:
2006.09.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to compounds according to the formula I: Where Ra is H or an optionally OH-substituted C1-C3 alkyl R1 is OR1, an optionally substituted C4-12 carbocyclic group which may be saturated or unsaturated (including aromatic) or an optionally substituted heterocyclic group R1 is an optionally substituted C1-C14 hydrocarbyl group or an optionally substituted heterocyclic group R2, R3 and R4 are each independently H, an optionally substituted C1-C4 alkyl group (preferably CH3, CH2CH3 or CF3), halogen (preferably F, Cl, Br), OR, CN, NO2, a C1-C6 thioether, a C1-C6 thioester group, an optionally substituted CO2R group, an optionally substituted COR group or an optionally substituted OCOR group (preferably R4 is H) R is H or an optionally substituted C1-C6 alkyl group RHET is an optionally substituted heterocyclic group and pharmaceutically acceptable salts, solvates or polymorphs thereof.
