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DEUTERATED ELAGOLIX-LIKE COMPOSITIONS AND METHODS
专利权人:
Lupin Inc.
发明人:
James Garegnani,Nicholas Hart,Richard Holl
申请号:
US16741677
公开号:
US20200268756A1
申请日:
2020.01.13
申请国别(地区):
US
年份:
2020
代理人:
摘要:
New deuterated analogs of elagolix are provided. The novel deuterated elagolix analogs differ from the only previously disclosed deuterated elagolix analogs in structure based on the exclusion of deuterium at certain sites in the compounds and the inclusion of deuterium at other sites. Also provided are new formulations for deuterated elagolix compounds and methods of using such compounds and formulations in the modification of mammalian physiology and especially in the treatment and prevention of a number of diseases and disorders, including endometriosis-associated pain and uterine fibroid conditions.
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