KIM, YONG ZU,OH, YEONG SOO,CHAE, JEIWOOK,SONG, HO YOUNG,CHUNG, CHUL-WOONG,PARK, YUN HEE,CHOI, HYO JUNG,PARK, KYUNG EUN,KIM, HYOUNGRAE,KIM, JINYEONG,MIN, JI YOUNG,KIM, SUNG MIN,LEE, BYUNG SOO,WOO, DONG
申请号：
CA3006247
公开号：
CA3006247A1
申请日:
2016.11.23
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
In some aspects, the inventionrelates to an antibody-drug conjugate, comprisingan antibody； a linker； and at least two active agents.In preferred embodiments, the linker comprises apeptide sequence of a plurality of amino acids, andat least two of the active agents are covalentlycoupled to side chains of the amino acids. The antibody-drugconjugate may comprise a self-immolativegroup, preferably two-self-immolative groups.The linker may comprise an O-substituted oxime,e.g., wherein the oxygen atom of the oxime is substitutedwith a group that covalently links theoxime to the active agent； and the carbon atom ofthe oxime is substituted with a group that covalentlylinks the oxime to the antibody.
