Park, Kyung Eun,Kim, Hyoungrae,Kim, Jinyeong,Min, Ji Young,Kim, Sung Min,Lee, Byung Soo,Woo, Dong Hyun,Jung, Ji Eun,Lee, Su In,Kim, Yong Zu,Oh, Yeong Soo,Chae, Jeiwook,Song, Ho Young,Chung, Chul-Woong
申请号：
AU2016359234
公开号：
AU2016359234A1
申请日:
2016.11.23
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody； a linker； and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime,
