Solidification factor or the effective tonnage of the mutein which it shares joins to the living body compatibility polymer of 1 or more with the amino acid region of 1 or more the hypodermic or the fact that the intracutaneous administration it does is included in the patient who needs remedy, remedy manner of the hemophilia.治療を必要とする患者に、1以上の生体適合性ポリマーに1以上のアミノ酸部位で共有結合した凝固因子またはそのムテインの有効量を皮下または皮内投与することを含む、血友病の治療方法。