This invention relates to methods of treating early enamel lesions comprising applying an effective amount of a basic amino acid in free or salt form, together with fluoride to a patient in need thereof.本發明係關於治療早期琺瑯質損害之方法,包括施用有效量之呈游離或鹽類形式之鹼性胺基酸,以及氟化物至有需要的患者。