A system and method for loading a guide wire into a medical device is provided. The medical device comprises a drive shaft having a lumen and a distal end and a guide wire loader having a distal end having a guide wire mating feature. In a preloaded state, at least a portion of the guide wire loader is disposed within the drive shaft lumen, and the distal end of the guide wire loader is disposed near the distal end the drive shaft. A guide wire has a loader mating feature on a proximal end of the guide wire that compliments the guide wire mating feature. To load the guide wire into the device, the loader mating feature of the guide wire is connected to the guide wire mating feature of the guide wire loader, and the guide wire loader shaft is moved axially in a proximal direction.
