DELTA12 DESATURASES SUITABLE FOR ALTERING LEVELS OF POLYUNSATURATED FATTY ACIDS IN OLEAGINOUS YEAST

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专利权人:

E.I. DUPONT DE NEMOURS AND COMPANY;YADAV, NARENDRA, S.;ZHU, QUINN, QUN;ZHANG, HONGXIANG

发明人:

YADAV, NARENDRA, S.,ZHU, QUINN, QUN,ZHANG, HONGXIANG

申请号：

WO2004US38034

公开号：

WO2005047485(A3)

申请日:

2004.11.12

申请国别(地区):

世界知识产权组织国际局

年份:

2006

代理人:

摘要：

The present invention relates to fungal ?12 fatty acid desaturases that are able to catalyze the conversion of oleic acid to linoleic acid (LA; 18:2). Nucleic acid sequences encoding the desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the desaturase genes, and recombinant host microorganisms expressing increased levels of the desaturases are described. Methods of increasing production of specific ?-3 and ?-6 fatty acids by over-expression of the ?12 fatty acid desaturases are also described herein.

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