Provided herein are compositions comprising synthetic lipase stimulating peptides and methods of treating hypertriglyceridemia and other conditions and diseases therewith. In particular synthetic peptides (AV peptides) and peptidomimetics (AV peptidomimetics) are provided that exhibit the lipase stimulating activity of apoA V or an enhancement thereof as well as methods of use thereof. Provided herein are compositions comprising a peptide or polypeptide having less than 100% sequence identity with full length ApoA V encompassing a portion with at least 50% sequence identity with AV199 224.
