A vessel sensing device with automatic amendment function includes an analog processing circuit, a signal generating circuit and a direct voltage detecting circuit. The analog processing circuit includes an optical sensing module. An optical sensor of the optical sensing module generates an analog signal with a skin characteristic signal and a vessel characteristic signal according to an optical reflecting signal. The skin characteristic signal and the vessel characteristic signal respectively correspond to a skin feature and a vessel feature of the user. The signal generating circuit is coupled to the analog processing circuit to transforms the analog signal into a compensating signal. The direct voltage detecting circuit is coupled to the signal generating circuit and adapted to compensate the analog processing circuit according to the compensating signal, so as to decrease the skin characteristic signal within the analog signal.一種具有校正功能的血管感測裝置,包含有一類比處理電路、一訊號產生電路以及一直流電壓偵測電路。該類比處理電路具有一光感測模組。該光感測模組之一感光元件根據一反射光訊號產生包含一皮膚特徵訊號與一血管特徵訊號的一類比訊號。該皮膚特徵訊號與該血管特徵訊號分別對應使用者的皮膚特徵和血管特徵。該訊號產生電路電連接於該類比處理電路,用以將該類比訊號轉換為一補償訊號。該直流電壓偵測電路電連接於該訊號產生電路。該直流電壓偵測電路依據該補償訊號補償該類比處理電路,以減少該類比訊號內的該皮膚特徵訊號。10‧‧‧血管感測裝置12‧‧‧類比處理電路14‧‧‧訊號產生電路16‧‧‧直流電壓偵測電路18‧‧‧光感測模組20‧‧‧增益模組22‧‧‧發光元件24‧‧‧感光元件26‧‧‧第一開關