This invention provides a compound of the formula (I): wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group； R<；SUP>；1 <；/SUP>；and R<；SUP>；2 <；/SUP>；independently represent a hydrogen atom or the like: R<；SUP>；3 <；/SUP>；and R<；SUP>；4 <；/SUP>；independently represent a hydrogen atom or the like: R<；SUP>；5 <；/SUP>；represents -CO<；SUB>；2<；/SUB>；H or the like: R<；SUP>；6 <；/SUP>；represents an alkyl group having from 1 to 6 carbon atoms or the like: X represents a methylene group or the like. These compounds are useful for the treatment of disease conditions mediated by prostaglandin such as pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.
