POOLMAN, JAN THEUNIS,JACQUEMYN, BERT,ABBANAT, DARREN ROBERT,YON, PATRICIA IBARRA,HERMANS, PETER WILHELMUS MARIA,KOWARIK, MICHAEL THOMAS,WETTER, MICHAEL LUKAS,KEMMLER, STEFAN JOCHEN,HAUPTLE, MICHA ANDR
申请号：
CA2995873
公开号：
CA2995873A1
申请日:
2016.08.24
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
