A surgical fixation cartridge (100), comprising: a cartridge body (112) that includes a tissue contact surface (120), the tissue contact surface including a plurality of fixing retention slots (126)； a plurality of surgical fixings (130) functionally arranged in the plurality of fixation retention slots； a plurality of pushers (150) functionally associated with the plurality of surgical fixings, each pusher being configured to eject an associated surgical fixation toward a depression (91) in an anvil (90)； and a drive slider (600) housed inside the cartridge body, the drive slider including a plurality of cam wedges (644), characterized in that the plurality of cam wedges are configured such that the wedges of Cams closest to a cutting line (122) are relatively stiffer compared to cam wedges farther from the cutting line, such that a surgical fixation (130) that is ejected closer to the cutting line produces a compression force in a stapled tissue superior to that of a surgical fixation ejected farther from the cutting line, and where the plurality of surgical fasteners (130) have a posterior connection (134) and legs (132), being extended at least some of the rear connections with respect to the legs.Un cartucho (100) de fijaciones quirúrgicas, que comprende: un cuerpo (112) de cartucho que incluye una superficie (120) de contacto con tejido, incluyendo la superficie de contacto con tejido una pluralidad de ranuras (126) de retención de fijaciones； una pluralidad de fijaciones quirúrgicas (130) dispuestas funcionalmente en la pluralidad de ranuras de retención de fijaciones； una pluralidad de empujadores (150) asociados funcionalmente a la pluralidad de fijaciones quirúrgicas, estando configurado cada empujador para expulsar una fijación quirúrgica asociada hacia una depresión (91) en un yunque (90)； y una corredera (600) de accionamiento alojada en el interior del cuerpo de cartucho, incluyendo la corredera de accionamiento una pluralidad de cuñas (644) de leva, c
