This invention inhibits cell breeding and cell division, inhibits the activation of transcription and the signal transmission with the mediation of hypoxia elicitor (HIF) under hypoxia condition, new chemical compound is offered. With one feature, as for the chemical compound of this invention, the inflammatory disease, the excessive vegetating disease or excessive vegetating fault, it is useful in remedy of the disease or the fault which is chosen from the group which consists of hypoxia-related lesion, and the disease which features the excessive vascular new life or preparation of the medicine for preventing. The chemical compound of this invention, and the useful 2nd curative medicine or radiation is included the disease or the fault which is referred in remedy or prevention, also the medicine constituent is offered. With 1st feature, as for this invention, it regards the chemical compound which possesses the structure due to formula (i).< Choice figure >Drawing 1本発明は、細胞増殖及び細胞分裂を阻害し、低酸素条件下において低酸素誘導因子(HIF)の媒介による転写及びシグナル伝達の活性化を阻害する、新規な化合物を提供する。一態様では、本発明の化合物は、炎症性疾患、過剰増殖性疾患又は過剰増殖性障害、低酸素関連病変、及び過剰な血管新生を特徴とする疾患からなる群から選択される疾患又は障害の治療又は予防のための薬物の調製に有用である。本発明の化合物、及び言及される疾患又は障害の治療又は予防に有用な第2の治療薬又は放射線を含む、医薬組成物も提供される。第1の態様では、本発明は、式(I)による構造を有する化合物に関する。【選択図】図1
