The embodiments disclosed herein relate to ophthalmic compositions comprisingcalcineurin inhibitors or mTOR inhibitors, and more particularly to methodsfor treating an ocular disease and/or condition using the disclosed compositions.According to aspects illustrated herein, there is provided a pharmaceuticalcomposition that includes a calcineurin inhibitor or an mTOR inhibitor； a firstsurfactant with an HLB index greater than about 10； and a second surfactant withan HLB index of greater than about 13, wherein an absolute difference betweenthe HLB index of the first surfactant and the HLB index of the second surfactantis greater than about 3, and wherein the composition forms mixed micelles.
