AN IMPROVED PROCESS FOR THE PREPARATION OF ARIPIPRAZOLE

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专利权人:

发明人:

SIRIPRAGADA MAHENDER RAO,NAGABUSHANAM NAGAMANI,SANTHOSH UNNI,Manoharan Muthu Tamizh

申请号：

IN1050/CHE/2006

公开号：

IN279496B

申请日:

2006.06.20

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

The present invention provides a process for the preparation of Aripiprazole, which comprise reacting 7-hydroxy-3,4dihydro-2(1H)quinolinone, 1,4-dichlorobutane, a base and dimethyl acetamide to obtain 7-(4-bromobutoxy)-3,4-dihydro-2-(1H)-quinolone and reacting 7-(4-bromobutoxy-3,4-dihydro-2-(1H)-quinolone, 1-(2,3-dichloropheny1) piperizine, a base and sodium iodide in dimethy1 acetamide

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