加利福尼亞大學董事會;The Regents of the University of California;加利福尼亚大学董事会
发明人:
P.芒斯特,J.克里亚吉斯,J.克里亞吉斯,H.斯比塔尼
申请号:
MOJ004142
公开号:
MOJ004142B
申请日:
2020.04.29
申请国别(地区):
MO
年份:
2020
代理人:
摘要:
An implant for delivering a hydrophobic active agent to a target tissue is provided herein.The implant may include: a scaffold defining a first surface and a second surface opposite to the first surface, wherein the scaffold is substantially impermeable with a hydrophobic active agent; and a silica gel tube with a wall permeable with the active agent, wherein the first length of the silicone tube is attached to the first surface of the scaffold, wherein both ends of the silicone tube extend from the first surface And in which the path drawn by the second length within the first length of the tube is circuitous.A method for topical delivery of a hydrophobic active agent to a target tissue using the implant and a kit for performing the method of the present invention are also provided.在此提供了一種用於將疏水性活性劑遞送到靶組織的植入物。該植入物可以包括:支架,該支架限定第一表面以及與該第一表面相對的第二表面,其中,該支架是疏水性活性劑基本上不可滲透的;以及具有該活性劑可滲透的壁的硅膠管,其中該硅膠管的第一長度貼附到該支架的第一表面,其中該硅膠管的兩端從該第一表面延伸出來,並且其中,由在該管的在第一長度內的第二長度擬出的路徑是迂回的。還提供了一種使用該植入物將疏水性活性劑局部遞送到靶組織的方法、以及可用於執行本發明方法的試劑盒。