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COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY
专利权人:
发明人:
Cecilia M. Bastos,Benito Munoz,Bradley Tait
申请号:
US15542997
公开号:
US20180147187A1
申请日:
2006.01.12
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present disclosure features compounds such as those having the Formulae (IIa), (IIb), (IIc), (IId), (IIIa), and (IIIb), which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound, such as a compound of Formula (IIa), (IIb), (IIc), (IId), (IIIa), or (IIIb).
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