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COMPOUNDS, COMPOSITIONS AND METHODS FOR INCREASING CFTR ACTIVITY
专利权人:
PROTEOSTASIS THERAPEUTICS; INC.
发明人:
BASTOS, CECILIA M.,MUNOZ, BENITO,TAIT, BRADLEY
申请号:
CA2973475
公开号:
CA2973475A1
申请日:
2016.01.12
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present disclosure features compounds such as those having the Formulae (Ila), (lIb), (lIc), (Ild), (IlIa), and (Illb), which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound, such as a compound of Formula (Ila), (lIb), (lIc), (lId), (IlIa), or (Illb).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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