Oklahoma Medical Research Foundation;Hough Ear Institute
发明人:
Richard D. KOPKE,Rheal A. TOWNER
申请号：
US15760779
公开号：
US20180256756A1
申请日:
2016.09.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed here is a method of transporting a therapeutic or diagnostic agent across a blood-brain barrier or a blood-cochlear barrier or a blood-cerebrospinal fluid barrier of a subject, comprising administering to a subject an amount of a therapeutic and/or diagnostic agent, along with an amount of 2,4-disulfonyl a-phenyl tertiary butyl nitrone (2,4-DSPBN), said therapeutic and/or diagnostic agent being characterized as being unable or poorly able, in the absence of said amount of 2,4-DSPBN, to cross the blood-brain barrier or the blood-cochlear barrier or the blood-cerebrospinal fluid barrier of said subject.
