對抗糖皮質激素誘導之腫瘤壞死因子受體（ＧＩＴＲ）之抗體及其用途农业专利-农业学术服务平台

发明人:: WANG, CHANGYU,王　章钰,王　章鈺,LONBERG, NILS,隆伯格　尼尔斯,隆伯格　尼爾斯,KORMAN, ALAN J.,寇曼　亚兰Ｊ,寇曼　亞蘭Ｊ,SELBY, MARK J.,赛尔比　马克Ｊ,賽爾比　馬克Ｊ,SRINIVASAN, MOHAN,史林维桑　摩汉,史林維桑　摩漢,HENNING, KARLA A.,翰宁　卡拉Ａ,翰寧　卡拉Ａ,HAN, MICHELLE MINHU,王章钰,王章鈺,隆伯格尼尔斯,隆伯格尼爾斯,寇曼亚兰J,寇曼亞蘭J,赛尔比马克J,賽爾比馬克J,史林维桑摩汉,史林維桑摩漢,翰宁卡拉A,翰寧卡拉A

摘要：: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.本文提供結合至糖皮質激素可誘導之TNF受體(GITR)之抗體或其抗原結合部分。亦提供該等蛋白質於治療應用，例如於癌症之治療中之用途。進一步提供產生該等抗體之細胞、編碼該等抗體之重鏈及/或輕鏈可變區之聚核苷酸及包含編碼該等抗體之重鏈及/或輕鏈可變區之該等聚核苷酸的載體。