REISCH, HELGE A.,SANDOVAL, SERGIO,STYMIEST, JAKE L.
申请号：
TW100120389
公开号：
TWI471289B
申请日:
2011.06.10
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines.
