Describes the use of a compound of the formula I in which X is 0, S, so 6 S02； r1 is trihalogenometilo, Oh, halogen, alkyl of C1 C1 - 7, 4 _ alkoxy, trifluoromethoxy, enoxi, ciclohexilmetiloxi, piridilmetoxi, cinamiloxi, naftilmetoxi, fenoximetilo - CH2 -, - Oh, - CH2 CH2 (Oh, c1-4 alkyl) - Uncle Alkyl (c1-4) sulfinilo, (c1-4 alkyl sulfonyl), benciltio, acetyl, Nitro or cyano, or phenylPHENYL alkyl of C1 - 4 0 - 4 - phenyl alkoxy C1 each phenyl Group of the same optionally replaced with NF3, halogen, alkyl or alkoxy C 1 - 4 4 _ C1, R2 is H, halogen, alkoxy trihalogenometilo, C 1 _ 4 alkyl of C1 - 1.Phenethyl or Benzyloxy 3； R H, halogen, alkyl of C1 CF3, Oh, _ 7 of c1-4 alkoxy, Benzyloxy phenyl alkoxy (or C1) - 4 - Methyl； each R4 and R5 are independently H or a residue of the formula (a) in which each one of R8 and R9, independently, is H or alkyl of C1 - 4 opcionalmen You replaced with hal6geno； and N is an integer from 1 to 4； or a pharmaceutically acceptable Salt,Solvate, hydrate, isomer or prodrug thereof； or a compound of the formula II in which trihalogenometilo A1A is Halogen, alkyl of C1 - 4, 4 _ alkoxy alkyl of C1, C1 _ 4) - Uncle, alkyl (C1 _ 4) - sulfinilo, alkyl sulfonyl _ 1 4) aralquilo phenoxy or substituted, optionally, aralqui Loxi, 2a is H, halogen, trihalogenometilo,C1-4 alkoxy or alkyl of C1 - 4 or 3 to 0 aralquilo aralquiloxi； R IS h, halogen, CF3, c1-4 alkyl, alkoxy alkyl of C1 _ 4 (c1-4) - Uncle or Benzyloxy； R4A is H, alkyl of C1 -, phenyl optionally substituted benzyl 4 aliphatic acyl or benzoyl or lower _ C1； 5 r5a is H, monohalogenom Ethyl, c1-4 alkyl.(C1 _ alkoxy alkyl (4) - methyl - 4 - tiometilo C1), hydroxyethyl, hydroxypropyl, phenyl, aralquilo, alquenilo C2 - 4 or alquinilo C2 - 4； r5a is H or alkyl C 1 _ R7a is H, 4； or a c1-4 alkyl residue formula (a) as defined above, XA is 0, S, so or so； and Na is a number RO integer from 1 to 4； or a pharmaceutically acceptable Salt, solvate, hydrate,Isomer or prodrug thereof, in the manufactur
