ALLEN, DANIEL REES,BÜRLI, ROLAND,HAUGHAN, ALAN FINDLAY,MATTEUCCI, MIZIO,OWENS, ANDREW PATE,RAPHY, GILLES,SHARPE, ANDREW
申请号：
ES10781864
公开号：
ES2520345T3
申请日:
2010.11.11
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: ** Formula ** wherein E represents a linear or branched C1-4 alkylene chain, optionally substituted with one or more substituents independently selected from trifluoromethyl, C 3-7 heterocycloalkyl, aryl, oxo, hydroxy, C 1-6 alkoxy, C 2-6 alkoxycarbonyl (C 1-6) alkoxy, aminocarbonyl-C 1-6 alkoxy, trifluoromethoxy, amino, C1-6-amino alkyl, dialkyl (C1-6) amino, aminocarbonyl, C1-6 alkylcarbonyl and dialkyl (C1-6) aminocarbonyl； Q represents oxygen, sulfur, N-R4 or a covalent bond； Z represents a bicyclic heteroaryl moiety consisting of two six-membered fused aromatic rings, the heteroaryl moiety Z containing at least one nitrogen atom and being linked to the rest of the molecule through a carbon atom, the heteroaryl moiety Z being optionally substituted with one or more substituents independently selected from halogen, cyano, nitro, C1-6 alkyl, trifluoromethyl, hydroxy, oxo, C1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C1-6-thio alkyl, C1-6-sulfinyl alkyl, alkyl C1-6-sulfonyl, amino, C1-6-amino alkyl, dialkyl (C1-6) amino, arylamino, C1-6-aryl-alkoxy (C1-6) amino, C2-6 alkylcarbonylamino, C1- alkyl 6-sulfonylamino, formyl, C2- 6-carbonyl alkyl, C3-6-cycloalkyl, C3-6-carbonyl heterocycloalkyl, carboxy, C2-6-carbonyl alkoxy, aminocarbonyl, C1-6-aminocarbonyl, dialkyl (C1-6 ) aminocarbonyl, aminosulfonyl, C1-6 alkyl-aminosulfonyl and dialkyl (C1-6) aminosulfonyl； M represents the residue of a saturated, five, six or seven membered monocyclic ring containing a nitrogen atom and 0, 1, 2 or 3 additional heteroatoms independently selected from N, O and S, but containing no more than one O or S atom, of whose monocyclic ring M is the residue that is optionally substituted with one or more substituents independently selected from halogen, C1-6 alkyl, heteroaryl, C1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C1-6 alkoxy (C1-6), C1-6-thio alkyl, C1-6-sulfonyl alkyl, h
