TELLERS, DAVID,COLLETTI, STEVEN L.,DUDKIN, VADIM,IKEMOTO, NORIHIRO,LIAO, HONGBIAO,PARISH, CRAIG,PEI, TAO,SHAW, ANTHONY,TRUONG, QUANG,WANG, LIJUN,YUAN, YU,ZHU, MAN
申请号:
CA2872100
公开号:
CA2872100A1
申请日:
2013.05.01
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.