PROBLEM TO BE SOLVED: To provide an isolated Tr1-like cell population capable of producing IL-13, the population having immunosuppressive activities, and a method for using the same.SOLUTION: According to the present invention, there is provided a human Tr1 cell population that can produce IL-13 in addition to IL-10, expresses CD4, the low levels of CD127, and the low levels of CD62L, specific for antigens, such as type II collagen, ovalbumin, myelin basic protein, and myelin oligodendrocyte protein； and are effective for prevention or treatment of immune response, graft-versus-host disease and organ rejection reactions, allergic diseases, inflammatory diseases, or autoimmune conditions.SELECTED DRAWING: None【課題】ＩＬ－１３を産生し免疫抑制活性を有する、単離されたＴｒ１－様細胞集団、並びにその使用方法の提供。【解決手段】ＩＬ－１０に加えＩＬ－１３を産生可能であって、ＣＤ４と低レベルのＣＤ１２７と低レベルのＣＤ６２Ｌを発現し、ＩＩ型コラーゲン、オボアルブミン、ミエリン塩基性タンパク質、ミエリンオリゴデンドロサイトタンパク質等の抗原に特異的であり、免疫反応、移植片対宿主病及び臓器拒絶反応、アレルギー疾患、炎症性疾患若しくは自己免疫状態を予防または治療に有効なヒトＴｒ１細胞集団の提供。【選択図】なし
