The United States of America; as represented by the Secretary; Department of Health and Human
发明人:
Ira H. Pastan,Ronit Mazor,Masanori Onda,Aaron Vassall,Richard Beers,Jaime Eberle,Wenhai Liu
申请号：
US15693705
公开号：
US20170369535A1
申请日:
2017.09.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
