THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
PASTAN, IRA H.,MAZOR, RONIT,ONDA, MASANORI,VASSALL, AARON,BEERS, RICHARD,EBERLE, JAIME,LIU, WENHAI
申请号：
CA2838013
公开号：
CA2838013A1
申请日:
2012.06.07
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
