An amine compound represented by the following formula (I) ** Formula ** wherein R is a hydrogen atom or P (>； = O) (OH) 2, X is an oxygen atom or a sulfur atom, Y is - CH2CH2- or -CH>； = CH-, Z is alkylene having 1 to 5 carbon atoms, alkenylene having 2 to 5 carbon atoms or alkynylene having 2 to 5 carbon atoms, R1 is trifluoromethyl, R2 is alkyl having 1 to 4 carbon atoms, which is optionally substituted with a hydroxyl group or halogen atom, R3 and R4 are optionally the same or different and each is a hydrogen or alkyl atom having 1 to 4 carbon atoms and A is optionally substituted aryl having 6 to 10 carbon atoms, optionally substituted heteroaryl having 5 to 10 ring constituent atoms, containing, as constituent ring atoms, 1 or 2 atoms of nitrogen atom, oxygen atom and atom sulfur, optionally substituted cycloalkyl having 3 to 7 atoms of carbon, which is optionally condensed with optionally substituted benzene or heterocycloalkyl having 5 to 7 ring constituent atoms, containing, as optionally substituted ring constituent atoms, 1 or 2 atoms of nitrogen atom and oxygen atom or one of its salts by the addition of pharmaceutically acceptable acids or one of its hydrates or one of its solvates.Un compuesto de amina representado por la siguiente fórmula (I)**Fórmula** en donde R es un átomo de hidrógeno o P(>；=O)(OH)2, X es un átomo de oxígeno o un átomo de azufre, Y es - CH2CH2- o -CH>；=CH-, Z es alquileno que tiene 1 a 5 átomos de carbono, alquenileno que tiene 2 a 5 átomos de carbono o alquinileno que tiene 2 a 5 átomos de carbono, R1 es trifluorometilo, R2 es alquilo que tiene 1 a 4 átomos de carbono, que está opcionalmente sustituido con un grupo hidroxilo o átomo de halógeno, R3 y R4 son opcionalmente iguales o diferentes y cada uno es un átomo de hidrógeno o alquilo que tiene 1 a 4 átomos de carbono y A es arilo opcionalmente sustituido que tiene 6 a 10 átomos de carbono, heteroarilo opcionalmente sustituido que tiene 5 a 10 átomos constituyentes del
