KAUFMAN, DAN SAMUEL,LAMPI HERMANSON, DAVID LEE,MORIARITY, BRANDEN SCOTT
申请号：
CA2975384
公开号：
CA2975384A1
申请日:
2016.01.28
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
This disclosure describes chimeric antigen receptors for expression in a Natural Killer (NK) cell, pharmaceutical compositions that include NK cells (and/or iPSCs) modified to express a chimeric antigen receptor, and methods involving such chimeric antigen receptors. Generally, the chimeric antigen receptor includes an ectodomain that includes an antigen recognition region, a transmembrane domain linked to the ectodomain, and an endodomain linked to the transmembrane domain. The endodomain can include a signaling peptide that activates an NK cell.
