Branden Moriarity;Regents of the University of Minnesota;Dan Kaufman;David Lampi Hermanson
发明人:
Kaufman, Dan Samuel,Lampi Hermanson, David Lee,Moriarity, Branden Scott
申请号：
AU2016211438
公开号：
AU2016211438A1
申请日:
2016.01.28
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
This disclosure describes chimeric antigen receptors for expression in a Natural Killer (NK) cell, pharmaceutical compositions that include NK cells (and/or iPSCs) modified to express a chimeric antigen receptor, and methods involving such chimeric antigen receptors. Generally, the chimeric antigen receptor includes an ectodomain that includes an antigen recognition region, a transmembrane domain linked to the ectodomain, and an endodomain linked to the transmembrane domain. The endodomain can include a signaling peptide that activates an NK cell.
