A leavened chew bone for pets and a method for preparing the leavened chew bone use wheat gluten, corn starch, and chicken or/and beef as main materials. The method involves steps of (1) dissolving, (2) activating yeast powder, (3) mixing, (4) slurry making, (5) fermenting and toughening, (6) forming, (7) leavening, and (8) heat-drying. The leavened chew bone such made is highly nutritional and has controlled hardness.