VISTICA, CYNTHIA A.,HOLMES, ERIC H.,BRAMS, PETER,WITTE, ALISON,CARDARELLI, JOSEPHINE M.
申请号：
PL06840172
公开号：
PL1960434T3
申请日:
2006.12.08
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
