Sirid-Aimee Kellermann,Larry L. Green,Wouter Korver
申请号：
US12577696
公开号：
US08198508B2
申请日:
2009.10.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present embodiments relate to methods of identifying and creating human or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for screening for anti-HAHA compounds are also included. Methods for determining if various conditions for administering an antibody to a subject enhance or suppress a HAHA response are also included. Some embodiments herein are directed to transgenic mouse embodiments relevant for HAHA responses.
