Five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis therapeutics

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专利权人:

Yi-Ling Lin;Chi-Huey Wong;Pi-Hui Liang

发明人:

Pi-Hui Liang,Yi-Ling Lin,Chi-Huey Wong

申请号：

US13033692

公开号：

US08273788B2

申请日:

2011.02.24

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Novel 5-membered iminocyclitol derivatives were found to be a potent and selective inhibitors of the glycoprotein processing α- and β-glucosidase which were further found to be active antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus and human β-hexosaminidase, a new target for development of osteoarthritis therapeutics.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/