isolated compound (ks 513) from pseudolysimachion rotundum var. subintegrum containing active ingredient, pharmaceutical composition and method for preventing or treating allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease, use thereof, functional and health care food
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;YUNGJIN PHARMACEUTICAL CO., LTD.
发明人:
BYUNG-HWAN RYOO,DAE-HEE SHIN,HYEONGKYU LEE,HYUK-HWAN SONG,HYUNG WON RYU,JI-SEOK YOO,KYUNG-SEOP AHN,SEI-RYANG OH,SU UI LEE,YONGNAM LEE
申请号：
BR112017008538
公开号：
BR112017008538A2
申请日:
2016.06.15
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
isolated compound (ks513) from pseudolysimachion rotundum var. subintegrum containing active ingredient, pharmaceutical composition and method for preventing or treating allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease, use thereof, functional and health care food refers to the compound (1as, 1bs, 2s, 4s , 5ar, 6s, 6as) -1a- (hydroxymethyl) -4-methoxy-2 - (((2s, 3r, 5s, 6r) -3,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2h-pyran -2-yl) oxy) octahydrooxy pyrene [2 ', 3': 4,5] cyclopenta [1,2-c] pyran-6-yl 4-hydroxybenzoate} (ks-513), isomer thereof, salt or solvates A pharmaceutically acceptable composition thereof, a composition comprising the same as an active ingredient for preventing or treating allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease (COPD) and the use thereof.composto (ks513) isolado de pseudolysimachion rotundum var. subintegrum contendo ingrediente ativo, composição farmacêutica e método para prevenir ou tratar doença alérgica, doença inflamatória, asma ou doença pulmonar obstrutiva crônica, uso da mesma, alimento funcional e de cuidado de saúde refere-se ao composto (1as,1bs,2s,4s,5ar,6s,6as)-1a-(hidroximetil)-4-metoxi-2-(((2s,3r,5s,6r)-3,4,5-trihidroxi-6-(hidroximetil)tetrahidro-2h-piran-2-il)oxi)octahidrooxireno[2',3':4,5]ciclopenta[1,2-c]piran-6-il 4-hidroxibenzoato} (ks-513), isômero do mesmo, o sal ou solvatos farmaceuticamente aceitáveis do mesmo, uma composição compreendendo o mesmo como um ingrediente ativo para prevenir ou tratar doença alérgica, doença inflamatória, asma ou doença pulmonar obstrutiva crônica (copd) e o uso da mesma.
