isolated compound of pseudolysimachion rotundum var. subintegrum containing active ingredient, pharmaceutical composition to prevent or treat allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and its use
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;YUNGJIN PHARMACEUTICAL CO., LTD.
发明人:
BYUNG-HWAN RYOO,DAE-HEE SHIN,HYEONGKYU LEE,HYUK-HWAN SONG,HYUNG WON RYU,IN SIK SHIN,JI-SEOK YOO,KYUNG-SEOP AHN,SEI-RYANG OH,SU UI LEE,YONGNAM LEE
申请号：
BR112017001364
公开号：
BR112017001364A2
申请日:
2015.07.22
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
isolated compound of pseudolysimachion rotundum var. subintegrum containing active ingredient, pharmaceutical composition to prevent or treat allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and its use, refers to the compound (3r, 5s, 5s, 6r, 7s, 8r, 8as) - 8-chloro-8α-hydroxy-5- (2-hydroxy acetoxy) hexahydro-1h-3,6-methanocyclopenta [e] [1,3] dioxepin-7-yl 3,4-dihydroxybenzoate (ks534), an isomer of same, a pharmaceutically acceptable salt or solvates thereof, a composition comprising it as an active ingredient for preventing or treating allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease (COPD) and use thereof.composto isolado de pseudolysimachion rotundum var. subintegrum contendo ingrediente ativo, composição farmacêutica para prevenir ou tratar doença alérgica, doença inflamatória, asma ou doença pulmonar obstrutiva crônica e o uso da mesma, refere-se ao composto (3r,5s,5as,6r,7s,8r,8as)-8-cloro-8a-hidroxi-5-(2-hidroxi acetoxi) hexahidro-1h-3,6-metanociclopenta[e][1,3]dioxepin-7-il 3,4-dihidroxibenzoato (ks534), um isômero do mesmo, um sal farmaceuticamente aceitável ou solvatos do mesmo, uma composição compreendendo o mesmo como um ingrediente ativo para prevenir ou tratar doença alérgica, doença inflamatória, asma ou doença pulmonar obstrutiva crônica (copd) e uso da mesma.
