Naimisha Trivedi;Diane Mary Coe;Helene Bazin-Lee;Stephen Allan Smith;Linos Lazarides;Charlotte Jane Mitchell
发明人:
Helene Bazin-Lee,Diane Mary Coe,Linos Lazarides,Charlotte Jane Mitchell,Stephen Allan Smith,Naimisha Trivedi
申请号:
US13058465
公开号:
US08563717B2
申请日:
2009.08.07
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to compounds of formula (I):wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure:n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.