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Quinazolinone derivatives substituted in position 6, 7 or 8 and compositions containing them and methods of use thereof
专利权人:
CELGENE CORPORATION
发明人:
MULLER, GEORGE,MAN, HON-WAH
申请号:
ES08834539
公开号:
ES2523925T3
申请日:
2008.09.25
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula (II), (V), or (VI): ** Formula ** Or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein: R7 is: halo; - (CH 2) noh; (C1-C6) alkyl, optionally substituted with one or more halo; or - (CH2) nnhrd, in which Rd is: Hydrogen; -C (O) - (CH2) n- (6 to 10-membered aryl), wherein the aryl is optionally substituted with one or more of: halo; - SCF3; (C1-C6) alkyl, optionally substituted with one or more halo; or (C1-C6) alkoxy, optionally substituted with one or more halo; -C (O) -C1-C8 alkyl, wherein the alkyl is optionally substituted with one or more halo; -C (O) - (CH2) n- (C3-C10 cycloalkyl); -C (O) - (CH2) n-nrerf, in which Re and Rf are each independently: Hydrogen; (C1-C6) alkyl, optionally substituted with one or more halo; or Aryl of 6 to 10 members, optionally substituted with one or more of: halo; (C1-C6) alkyl, optionally substituted with one or more halo; or (C1-C6) alkoxy, optionally substituted with one or more halo; -C (O) - (CH2) n-O-(C1-C6) alkyl; or -C (O) - (CH2) n-O- (CH2) n- (aryl of 6 to 10 members); R8 is: hydrogen or (C1-C6) alkyl, optionally substituted with one or more halo; R9 is hydrogen; R15 is: halo; - (CH2) noh; (C1-C6) alkyl, optionally substituted with one or more halo; or - (CH2) nnhrj, in which Rj is: Hydrogen; or -C (O) -C1-C8 alkyl, wherein the alkyl is optionally substituted with one or more halo; R16 is: hydrogen or (C1-C6) alkyl, optionally substituted with one or more halo; R17 is: hydrogen; R18 is: halo; - (CH2) noh; or (C1-C6) alkyl, optionally substituted with one or more halo; R19 is: hydrogen or (C1-C6) alkyl, optionally substituted with one or more halo; R20 is: hydrogen; and N is 0, 1, or 2.Un compuesto de fórmula (II), (V), o (VI):**Fórmula** O una sal farmacéuticamente aceptable, solvato, o estereoisómero de éste, en el que: R7 es: halo; -(CH 2)noh; alquilo(C1-C6), sustituido opcionalmente con uno o más halo; o -(CH2)nnhrd, en el que Rd es: Hidrógeno; -C(O)-(CH2)n-(arilo de 6
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