The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds.PKR activator compounds useful in the treatment of diseases and disorders associated with PKR and/or PKM2.本揭露係關於調節丙酮酸激酶,且提供用作PKR之活化劑之新穎化學化合物,以及此等化合物PKR活化劑化合物用於治療與PKR及/或PKM2相關之疾病及病症之各種用途。