Anna ERICSSON,Neal GREEN,Gary GUSTAFSON,Bingsong HAN,David R. LANCIA, Jr.,Lorna MITCHELL,David RICHARD,Tatiana SHELEKHIN,Chase C. SMITH,Zhongguo WANG,Xiaozhang ZHENG
申请号：
US16496279
公开号：
US20200069643A1
申请日:
2018.03.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds of formula (I) useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
