Marina Cardó-Vila,Ricardo J. Giordano,John Mendelsohn,Wadih Arap,Renata Pasqualini
申请号：
US13577809
公开号：
US20130059793A1
申请日:
2011.02.08
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided are peptides which can mimic the epidermal growth factor receptor (EGFR), e.g., by selectively binding TGF-α and/or EGF. In certain embodiments, the peptides are retro-inverted peptides. The peptides may be used as soluble decoys for TGF-α and/or EGF, and anti-cancer properties of peptides are demonstrated both in vitro and in vivo. The peptides may be administered alone or comprised in a fusion construct, imaging construct, and/or a therapeutic construct, e.g., for the treatment of a cancer.
