Joseph E. Blaney,Jason Paragas,Peter Jahrling,Reed Johnson,Matthias Schnell
申请号：
US13983545
公开号：
US20140212434A1
申请日:
2012.02.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector omprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compostions comprising the vaccine vectors.
