federalnoe gosudarstvennoe byudzhetnoe uchrezhdenie "Natsionalnyj issledovatelskij tsentr epidemiologii i mikrobiologii imeni pochetnogo akademika N.F.Gamalei" Ministerstva zdravookhraneniya Rossijsko
发明人:
Shmarov Maksim Mikhajlovich,Шмаров Максим Михайлович,Tillib Sergej Vladimirovich,Тиллиб Сергей Владимирович,Tutykhina Irina Leonidovna,Тутыхина Ирина Леонидовна,Rutovskaya Marina Vladimirovna,Рутовска
申请号：
RU2016144379
公开号：
RU0002661028C2
申请日:
2016.11.11
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: group of inventions relates to medicine, namely to immunology, and can be used to produce a pharmaceutical kit for passive rabies immunization. Pharmaceutical kit placed in an acceptable package comprises: 1) a pharmaceutical composition comprising virus neutralizing anti-rabies single-domain antibodies in an effective amount and a pharmaceutically acceptable buffer solution up to 1 ml, wherein the virus neutralizing anti-rabies single-domain antibodies have an amino acid sequence SEQ ID NO.1 wherein an effective dose of virus neutralizing anti-rabies single-domain antibodies is a dose of not less than 150 ME activity, in lyophilized form 2) a pharmaceutical composition comprising recombinant pseudo-adenovirus particles carrying a gene of virus neutralizing anti-rabies single-domain antibodies in an effective amount, a pharmaceutically acceptable buffer solution up to 1 ml recombinant pseudo-adenovirus particles carrying a gene for virus neutralizing anti-rabies single-domain antibodies have a nucleotide sequence of a genetic insert SEQ ID NO.3, and an effective dose of recombinant pseudo-adenovirus particles carrying a gene of virus neutralizing anti-rabies single-domain antibodies is at least 5×108 PFU in 1 ml of a pharmaceutically acceptable solvent 3) instructions for the administration of this pharmaceutical kit. Group of inventions also relates to the use of a pharmaceutical kit for passive rabies immunization.EFFECT: use of this group of inventions provides emergency prevention of rabies through passive immunization by using the produced pharmaceutical compositions, action of which begins with 6 hours of administration and lasts up to 7 days.2 cl, 12 ex, 4 tbl, 6 dwgГруппа изобретений относится к медицине, а именно к иммунологии, и может быть использована для получения фармацевтического набора для пассивной иммунизации против бешенства. Фармацевтический набор, помещенный в приемлемую упаковку, включает: 1) фармацевтическую композици
