Christopher McGuigan,Jan Balzarini,Magdalena Slusarczyk,Blanka Gonczy,Paola Murziani
申请号:
US14560097
公开号:
US20150183817A1
申请日:
2014.12.04
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.