The present invention has an object to provide a drug packaging device including a printing unit configured to perform printing by jetting ink and being capable of performing the printing on a packaging paper with high printing quality without including a support base or the like for the packaging paper. A drug packaging device (10) includes a drug supply unit (20), a packaging unit (30), a packaging paper conveying unit (40), and a printing unit (60). The printing unit (60) includes an ink ejection unit (62) capable of ejecting ink downward. A conveyance path (T) of the packaging paper conveying unit (40) includes: an intersecting-direction conveyance section (T1) for conveying a packaging paper (S) in a direction intersecting an ejection direction of the ink; and a first conveyance direction switching section (46) and a second conveyance direction switching section (48) for changing the conveyance direction of the packaging paper (S) on upstream and downstream, respectively, of the intersecting-direction conveyance section (T1) in a conveyance direction of the packaging paper (S). The ink ejection unit (62) is arranged at a position spaced apart upward from the intersecting-direction conveyance section (T1) by a predetermined distance.