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METHOD FOR THE IDENTIFICATION BY MOLECULAR TECHNIQUES OF GENETIC VARIANTS THAT ENCODE NO D ANTIGEN (D-) AND ALTERED C ANTIGEN (C+W)
专利权人:
发明人:
Jorge Ochoa,Monica Lopez,Diego Tejedor,Antonio Martinez,Laureano Simon
申请号:
US14938405
公开号:
US20160060696A1
申请日:
2015.11.11
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The invention relates to genotyping and blood cell antigen determination. In particular, the invention addresses discriminating the RHD*DIIIa-CE(4-7)-D or RHD*DIIIa-CE(4-7)-D)-like blood type variants, from RHD*DIIIa, RHD*DIVa-2 and other blood type variants. The invention provides methods for genotyping a subject, comprising determining at least 4 markers in a sample that has been obtained from the subject, wherein the markers comprise:(i) the presence or absence of an RHCE*C allele(ii) the presence or absence of an RHD/RHCE hybrid exon 3 (RHD/CE Hex03) allele(iii) the absence of, or a single nucleotide polymorphism (SNP) variant within, any one of position 602 of exon 4, position 667 of exon 5, or position 819 of exon 6 of RHD and(iv) the absence of, or SNP variant within, position 1048 of RHD exon 7.The invention also provides probes, primers and kits for use in such methods.
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