Rafael LEON MARTINEZ,Izaskun BUENDIA ABAITUA,Elisa NAVARRO GONZALEZ DE MESA,Patrycja MICHALSKA,Isabel GAMEIRO ROS,Alicia LOPEZ VIVO,Javier EGEA MAIQUEZ,Manuela GARCIA LOPEZ,Antonio GARCIA GARCIA
申请号：
US15518223
公开号：
US20180105492A1
申请日:
2015.10.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to the methods for producing derivatives of 3-alkylamino-1H-indole acrylate (I) with transcription factor Nrf2-inducing activity, free radical scavenging activity and neuroprotective ability. The invention also relates to the use of the derivatives according to the invention for the treatment of diseases, the pathogenesis of which involves oxidative stress, or diseases involving the deregulation of the activity of phase II genes activated by the factor Nrf2, such as Alzheimers disease, Parkinsons disease, Huntingtons disease, multiple sclerosis, ictus or amyotrophic lateral sclerosis.
